Calcified lesions

Find all the latest content on calcified lesions published on this website.

This section revolves around the complexity of calcified coronary lesions and their treatment, from specialised balloon technology to atherectomy devices and lithotripsy. Learn all about the value of invasive imaging and coronary physiology, with many clinical cases showing various treatment modalities and strategies.

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Balloon lithotripsy added to conventional preparation before stent implantation in severely calcified coronary lesions

06 Jan 2026

In patients with severely calcified coronary lesions undergoing PCI, the BALI trial evaluated the benefit of the addition of intravascular lithotripsy to conventional lesion preparation on the composite endpoint of procedural failure and target vessel failure.

Nicola Ryan

Reviewer

Nicola Ryan
Balloon lithotripsy added to conventional preparation before stent implantation in severely calcified coronary lesions

Coronary Pot Pourri - 2

11 Dec 2025 – From GulfPCR-GIM 2025

This session presents a diverse range of complex coronary interventions, highlighting advanced techniques and strategies. Topics include the use of ECMO support for high-risk PCI and TAVI in cardiogenic shock, innovative approaches in left main interventions, challenging stent optimisation, and management of patients with combined severe...

NIRS-guided PCI: beyond calcium to precision PCI

11 Dec 2025 – From GulfPCR-GIM 2025

This session highlights the utility of Near-Infrared Spectroscopy (NIRS) in guiding precise PCI beyond traditional angiographic assessment. It covers identification of vulnerable lipid-rich plaques, optimization of lesion preparation using atherectomy or lithotripsy when indicated, and improving stent deployment through integrated NIRS and IVUS guidance. Case presentations...

NIRS-guided PCI: beyond calcium to precision PCI

Abstracts - Part 2

11 Dec 2025 – From GulfPCR-GIM 2025

This session compiles recent clinical abstracts addressing diverse topics in interventional cardiology. Highlights include the HYBRID-CTO approach from a prospective case series, the cardiovascular impact of empagliflozin in type 2 diabetes, off-label use of intravascular lithotripsy for resistant in-stent lesions, and experiences with non-hyperaemic pressure ratios...

Calcified lesions: LIVE Educational Case from King Faisal Cardiac Center, National Guard Health Affairs- Western region - Jeddah, Saudi Arabia

11 Dec 2025 – From GulfPCR-GIM 2025

This educational session from King Faisal Cardiac Center provides a detailed examination of optimal device use in calcified coronary lesions, emphasizing the role of intracoronary imaging to improve PCI results and patient outcomes. It also offers guidance on selecting appropriate strategies for coronary bifurcation lesions through...

Complication session

11 Dec 2025 – From GulfPCR-GIM 2025

This session addresses complex coronary complications through a series of challenging cases including dextrocardia with acute STEMI, fragile coronary anatomy risks, left main complications, and stent-related issues. It provides critical insights into recognizing and managing unexpected procedural challenges to improve patient safety.

Complication session

Calcified lesions: caught between a rock and a hard place

10 Dec 2025 – From GulfPCR-GIM 2025

This session focuses on the challenges of treating calcified coronary lesions, emphasizing the use of intravascular ultrasound (IVUS)-guided rotablation and the limitations of rotatripsy in complex bifurcation angioplasty. It covers innovative strategies including off-label Shockwave lithotripsy in stented lesions, management of calcified nodules, and approaches to...

Challenging cases from the East

10 Dec 2025 – From GulfPCR-GIM 2025

This session from Eastern cardiology centers addresses complex interventional challenges including recurrent left internal mammary artery (LIMA) failure, management of transcatheter aortic valve implantation (TAVI) complications, and treatment of heavily calcified coronary lesions. Through detailed case presentations and key learnings, it offers valuable insights into successful...

Challenging cases from the East

Cracking calcium in modern PCI

10 Dec 2025 – From GulfPCR-GIM 2025

Calcified coronary lesions are a major challenge in PCI. This PCRGulf-GIM 2025 session showcases a complex case with intravascular imaging, highlighting how IVUS 123 guides each step.

From planning the procedure and understanding calcium distribution, to lesion preparation with modern modification tools, and post-PCI assessment to confirm...

Cracking calcium in modern PCI

Seeing is believing: OCT-guided calcium modification in complex PCI

10 Dec 2025 – From GulfPCR-GIM 2025

Explore the management of heavily calcified LAD lesions in this PCRGulf-GIM 2025 session. Discover how OCT imaging guides lesion assessment, differentiates superficial from deep calcium, and informs the need for plaque modification. Learn when and how to use orbital atherectomy or intravascular lithotripsy, and follow the...

Seeing is believing: OCT-guided calcium modification in complex PCI

Complex bifurcation interventions

10 Dec 2025 – From GulfPCR-GIM 2025

This session examines complex bifurcation interventions, addressing challenging cases such as isolated Medina 0,0,1 left main bifurcation and imaging-guided trifurcation angioplasty in acute coronary syndromes. It emphasizes strategic approaches and device selection to overcome anatomical complexities, manage complications, and achieve successful outcomes in bifurcation PCI.

Abstracts session 1

10 Dec 2025 – From GulfPCR-GIM 2025

This abstracts session presents contemporary research and clinical insights in interventional cardiology, covering topics such as colchicine therapy post-stenting, ranolazine use in chronic coronary syndrome, artificial intelligence applications in quantitative coronary analysis, and optimization techniques in transcatheter aortic valve implantation. It also explores novel predictors of...

A randomised, multicenter, non-inferiority comparison of intravascular lithotripsy and super-high-pressure non-compliant balloons for treatment of calcified and refractory coronary lesions - The VICTORY trial

27 Oct 2025

Mirvat Alasnag provides her take on the VICTORY trial presented by Matthias Bossard at TCT 2025 in San Francisco.

Dr. Mirvat Alasnag

Author

Mirvat Alasnag
VICTORY: Intravascular lithotripsy vs. super-high-pressure PTCA in calcified and refractory coronary lesions

Calcified coronary lesions

21 Oct 2025

This freshly updated chapter extensively describes percutaneous tools and techniques to assess and treat challenging calcified lesions.

Authors :

Farrel Hellig, Pieter Van Wyk, Emanuele Barbato, Shaheen Pandie
Calcified coronary lesions

Provisional stenting with a scaffold stent and DCB in calcified left main bifucation - LIVE Case

11 Oct 2025 – From AICT-AsiaPCR 2025

A 59-year-old male presented with CCS for three months, with diabetes and normal LV function (72%). Coronary angiography showed a calcified left main stenosis (Medina 1,1,1) and diffuse calcification of the proximal and mid LAD. The LCX QFR was 0.86.

Treatment included extensive lesion preparation with lithotripsy...

Provisional stenting with a scaffold stent and DCB in calcified left main bifucation - LIVE Case

Coronary complications and rescue cases

11 Oct 2025 – From AICT-AsiaPCR 2025

This compelling session addresses complex coronary complications and rescue cases encountered in the cath lab. Through a series of challenging case studies, it highlights critical scenarios such as silent coronary artery threats, procedural nightmares, coronary perforations, and innovative rescue strategies that transform high-risk situations into successful...

Coronary complications and rescue cases

Retrievals, foreign bodies and entrapments

11 Oct 2025 – From AICT-AsiaPCR 2025

This session addresses the complexities of retrievals, foreign bodies, and entrapments in interventional cardiology. It presents clinical cases illustrating percutaneous retrieval techniques, management of catheter fractures, iatrogenic dissections, and innovative solutions for challenging scenarios. Emphasis is placed on precision, prevention strategies, and effective problem-solving to mitigate...

PCR @ TCT 2025 - Get the international perspective!

15 Oct 2025

Thanks to the contribution of a team of interventional cardiologists from around the globe, get the international perspective on Late-breaking Clinical Trials and Science released at TCT 2025 - check out the list below.

PCRonline @ TCT 2025 - get the international perspective!

Calcium nodule in circumflex ostium: a complex problem

31 Oct 2025

Analyse this case of an 83-year-old male patient, hypertensive, ex-smoker, with severe COPD and peripheral arterial disease with unstable angina. Coronary angiography revealed a severely calcified lesion in a complex anatomical area, making revascularisation a therapeutic challenge.

Jorge Perea

Author

Jorge Perea
Javier Suarez de Lezo

Author

Javier Suarez de Lezo
Soledad Ojeda

Author

Soledad Ojeda
Prof. Manuel Pan

Author

Manuel Pan
Calcium nodule in circumflex ostium: a complex problem

Optical coherence tomography- vs angiography-guided coronary stent implantation in calcified lesions: the ILUMIEN IV trial

28 Aug 2025

In the overall population (n = 2,114), there was a significant interaction between the effect of randomisation to OCT guidance vs angiography guidance in lesions with moderate/severe calcification (n = 1,082) vs no/mild calcification (n = 1,032) on the 2-year rate of TVF (Pinteraction = 0.01).

Reviewer

Salvatore Brugaletta
OCT- vs angiography-guided coronary stent implantation in calcified lesions: the ILUMIEN IV trial